554 5.7.1 This email has been rejected. The email message was detected as spam

we are running Exchange 2007, for few days now, couple users cannot sent emails to few email addresses.

below is the header:

Diagnostic information for administrators:

Generating server:  xyz.org 

info@recipient_address
mail.xyz.org #554 5.7.1 This email has been rejected. The email message was detected as spam. ##

Original message headers:

Received: from XYZ ([2002:c064:1e27::c064:1e27]) by
 mail.xyz.org ([2002:c064:1e27::c064:1e27]) with mapi; Mon, 20 May 2013
 08:52:44 -0400
From: My staff
To: Ryan <info@recipient_address>
Date: Mon, 20 May 2013 08:51:42 -0400
Subject: site corrections & update
Thread-Topic: site corrections & update
Thread-Index: Ac5UEwbB0dxeqcHJROWqKc2nwNCXKQBRcAbo
Message-ID: <921AB2052801504C94D1F0DC47EA436ACE12519AFC@mail.xyz.org>
References: <921AB2052801504C94D1F0DC47EA436ACDFDC8DDFC@mail.xyz.org>,<1368914390.25774.YahooMailNeo@web5703.biz.mail.ne1.yahoo.com>
In-Reply-To: <1368914390.25774.YahooMailNeo@web5703.biz.mail.ne1.yahoo.com>
Accept-Language: en-US
Content-Language: en-US
X-MS-Has-Attach:
X-MS-TNEF-Correlator:
acceptlanguage: en-US
Content-Type: multipart/alternative;
	boundary="_000_921AB2052801504C94D1F0DC47EA436ACE12519AFC_"
MIME-Version: 1.0

Please HELP!